The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
Eur Heart J. 2011 Dec;32(24):3088-97. doi: 10.1093/eurheartj/ehr275. Epub 2011 Aug 6.
Blood pressure tracking can be used to examine the predictability of future values by early measurements. In a population-based prospective cohort study, among 8482 pregnant women, we examined whether blood pressure in early pregnancy tracks to third trimester and whether this tracking is influenced by maternal characteristics and is associated with the risk of gestational hypertensive disorders.
Blood pressure was measured in each trimester of pregnancy. Information about doctor-diagnosed pregnancy-induced hypertension and preeclampsia was obtained from medical records. Correlation coefficients between first and third trimester for systolic and diastolic blood pressure were 0.47 and 0.46, respectively. The odds ratio for staying in the highest tertile from first to third trimester for systolic blood pressure was 3.09 [95% confidence interval (CI): 2.73, 3.50] and for diastolic blood pressure 3.28 (95% CI: 2.90, 3.69). Blood pressure tracking coefficients were lower in younger, shorter, and non-European women and in women with higher gestational weight gain. Systolic and diastolic blood pressure changes from second to third trimester, but not from first to second trimester, were positively associated with the risks of pregnancy-induced hypertension and preeclampsia.
Blood pressure tracks moderately during pregnancy and is influenced by maternal characteristics. Second to third trimester increases in systolic and diastolic blood pressure are associated with an increased risk of gestational hypertensive disorders.
血压跟踪可用于通过早期测量来检查未来值的可预测性。在一项基于人群的前瞻性队列研究中，我们在 8482 名孕妇中检查了妊娠早期的血压是否会跟踪到孕晚期，以及这种跟踪是否受母体特征的影响，并与妊娠期高血压疾病的风险相关。
在妊娠的每个 trimester 测量血压。从病历中获取关于医生诊断的妊娠高血压和子痫前期的信息。收缩压和舒张压的第一和第三 trimester 之间的相关系数分别为 0.47 和 0.46。从第一到第三 trimester 收缩压保持在最高三分位的比值比为 3.09（95%置信区间：2.73，3.50），舒张压为 3.28（95%置信区间：2.90，3.69）。在年轻、身材矮小、非欧洲裔的女性以及妊娠体重增加较多的女性中，血压跟踪系数较低。从第二到第三 trimester 的收缩压和舒张压变化与妊娠高血压和子痫前期的风险呈正相关，但从第一到第二 trimester 的变化没有。
血压在怀孕期间有一定程度的跟踪，受母体特征的影响。从第二到第三 trimester 的收缩压和舒张压的增加与妊娠期高血压疾病的风险增加相关。
