Arch Gynecol Obstet. 2011 Dec;284(6):1589-91. doi: 10.1007/s00404-011-2036-1. Epub 2011 Aug 7.
Epithelioid hemangioendothelioma (EHE) is an unusual vascular tumor, which usually occurs in the soft tissue, liver, breast, lung and bone. We submit a case of EHE, a tumor never before reported in the ovary. A 20-year-old woman was admitted with a medical history of unilateral ovarian tumor. The right ovary was totally removed and histologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and prominent intracytoplasmic vacuoles associated with myxohyaline matrix. No morphologic evidence of germ cell tumor was observed. Immunohistochemically, the tumor cells were positive for CD31 and CD34. However, all germ cell tumor markers were negative. The final diagnosis was EHE of the ovarian gland and sarcomatous transformation in ovarian germ cell tumor was excluded after extensive histopathological and immunohistochemical study. EHE is an uncommon vascular tumor, which is rarely seen in female genital tract and this is the first report of EHE in ovarian gland. Final diagnosis depends on histopathological and immunohistochemical features.
上皮样血管内皮细胞瘤（EHE）是一种不常见的血管肿瘤，通常发生在软组织、肝脏、乳腺、肺和骨。我们报告一例 EHE，这是一种以前从未在卵巢中报道过的肿瘤。一名 20 岁女性因单侧卵巢肿瘤病史入院。行右侧卵巢全切除术，组织学上，肿瘤由具有嗜酸性细胞质和突出的细胞内空泡的上皮样细胞组成，伴有黏液样基质。未见生殖细胞肿瘤的形态学证据。免疫组化染色显示肿瘤细胞 CD31 和 CD34 阳性。然而，所有生殖细胞肿瘤标志物均为阴性。最终诊断为卵巢腺上皮样血管内皮细胞瘤，经广泛的组织病理学和免疫组织化学研究排除了卵巢生殖细胞肿瘤的肉瘤样转化。EHE 是一种不常见的血管肿瘤，在女性生殖道中很少见，这是首例在卵巢中报道的 EHE。最终诊断取决于组织病理学和免疫组织化学特征。
