Dundr Pavel, Němejcová Kristýna, Laco Jan, Skálová Helena, Bauerová Lenka, Matěj Radoslav, Fischerová Daniela
Department of Pathology, First Faculty of Medicine Charles University and General University Hospital in Prague, Studnickova 2, 12800, Prague 2, Czech Republic.
The Fingerland Department of Pathology, Charles University, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Pathol Oncol Res. 2017 Oct;23(4):717-722. doi: 10.1007/s12253-016-0186-y. Epub 2017 Jan 3.
We report six cases of anastomosing hemangioma of the ovary. All lesions were unilateral and arose in 43 to 81 year old females. In all but one patient, the tumor was asymptomatic and represented incidental finding. The exception was a tumor associated with massive ascites and elevated CA 125. The tumors were, on cut section, spongy and dark violet in color. The size of tumors ranged from 0.5 to 3.5 cm. All lesions showed the same histological features and consisted of capillary sized anastomosing vessels with sinusoid-like pattern intermingled with sporadic medium sized vessels. Interestingly, in all cases there were areas of luteinized cells at the tumor periphery, which ranged from rare small nests to multiple and commonly confluent areas. In one tumor, components of mature adipose tissue were present. Immunohistochemically, all tumors were CD31 and CD34 positive. Other markers examined were negative, including; estrogen receptor, progesterone receptor, androgen receptor, and D2-40. Proliferative activity (Ki-67 index) was very low in all cases. Anastomosing hemangioma is a rare entity, only 8 lesions occurring in ovary has been described from its initial description in 2009. We report six additional cases with their clinicopathological correlation.
我们报告6例卵巢吻合性血管瘤。所有病变均为单侧，发生于43至81岁的女性。除1例患者外，其余患者的肿瘤均无症状，为偶然发现。例外的是1例伴有大量腹水和CA 125升高的肿瘤。肿瘤切面呈海绵状，颜色为深紫色。肿瘤大小为0.5至3.5厘米。所有病变均表现出相同的组织学特征，由毛细血管大小的吻合血管组成，呈窦状模式，夹杂着散在的中等大小血管。有趣的是，所有病例中肿瘤周边均有黄素化细胞区域，范围从罕见的小巢状到多个且通常融合的区域。在1例肿瘤中，存在成熟脂肪组织成分。免疫组化显示，所有肿瘤CD31和CD34均呈阳性。检测的其他标志物均为阴性，包括雌激素受体、孕激素受体、雄激素受体和D2-40。所有病例的增殖活性（Ki-67指数）均非常低。吻合性血管瘤是一种罕见的病变，自2009年首次描述以来，仅有8例发生于卵巢的病例被报道。我们报告另外6例病例及其临床病理相关性。
