[精子DNA损伤与不明原因复发性自然流产]
[Sperm DNA damage and unexplained recurrent spontaneous abortion].
作者信息
Liu Cheng-Jun, Wang Ai-Ming, Shang Wei, Li Min, Wang Wei-Zhou, Shen Yu-Liang, Zhao Yong
机构信息
Reproductive Center, Navy General Hospital, Beijing 100048, China.
出版信息
Zhonghua Nan Ke Xue. 2011 Jul;17(7):619-21.
OBJECTIVE
To explore the relationship of sperm DNA damage with unexplained recurrent spontaneous abortion (URSA).
METHODS
Sperm DNA fragmentation was evaluated by sperm chromatin dispersion (SCD), and the results were expressed in terms of DNA fragmentation index (DFI). DFIs were measured in the male partners of 56 women with URSA (the experiment group) and of 31 without URSA (the control group).
RESULTS
The DFI was shown to be (11.0% - 56.9%) in the experiment group, 21 (37.5%) of the subjects over 30%, as compared with (10.0% -36.8%) in the control group, only 8 (25.8%) of the subjects over 30%, significantly higher in the former than in the latter (29.4% vs 25.5%, P < 0.05).
CONCLUSION
There is a relationship between sperm DNA damage and URSA.
目的
探讨精子DNA损伤与不明原因复发性自然流产（URSA）之间的关系。
方法
采用精子染色质扩散试验（SCD）评估精子DNA碎片化情况，结果以DNA碎片化指数（DFI）表示。对56例不明原因复发性自然流产女性的男性伴侣（实验组）和31例无不明原因复发性自然流产女性的男性伴侣（对照组）进行DFI检测。
结果
实验组DFI为（11.0% - 56.9%），其中21例（37.5%）受试者DFI超过30%；对照组DFI为（10.0% - 36.8%），仅8例（25.8%）受试者DFI超过30%，实验组显著高于对照组（29.4%对25.5%，P < 0.05）。
结论
精子DNA损伤与不明原因复发性自然流产之间存在关联。
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