Li Xia-Yun, Liu Ying-Jie, Hou Ling-Ling, Wang Kai-Gong, Guan Wei-Jun, Ma Yue-Hui
Beijing Institute of Veterinary Medicine, Chinese Academy of Agricultural Science, Beijing 100193, China.
Zhonghua Nan Ke Xue. 2011 Jul;17(7):628-33.
The glial cell-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta (Tgf-beta) superfamily, which is produced by Sertoli cells and plays an important role in the proliferation and differentiation of spermatogonial stem cells (SSC). The addition of proper amount of GDNF to the culture media can promote SSC proliferation in vitro. Besides, GDNF regulates the self-renewal and differentiation of SSCs through various signaling pathways. This review focuses on the effects of GDNF on the proliferation and differentiation of mammalian SSCs and GDNF-mediated signaling pathways.
胶质细胞源性神经营养因子（GDNF）是转化生长因子β（Tgf-β）超家族的成员，由支持细胞产生，在精原干细胞（SSC）的增殖和分化中起重要作用。向培养基中添加适量的GDNF可促进体外SSC增殖。此外，GDNF通过多种信号通路调节SSC的自我更新和分化。本文综述了GDNF对哺乳动物SSC增殖和分化的影响以及GDNF介导的信号通路。
