Ma Jian-Guo, Li Wen-Ping, Jiang Yu-Qing
Department of Urology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.
Zhonghua Nan Ke Xue. 2011 Jul;17(7):649-54.
Prostate cancer growth is almost wholly dependent on the route of the androgen receptor and most therapies aimed at blocking this signaling axis are useful tools in the management of this disease. Unfortunately such therapies invariably fail, and the cancer progresses to an androgen-independent stage. In such cases, androgen receptor mutation almost always occurs and much evidence suggests the continuous growth of the tumor. One mechanism by which the receptor is thought to remain active is mutation. This paper reviews the molecular mechanism of tumor growing after androgen receptor mutation and some of the promising management principles and systemic chemotherapy options against prostate cancer.
前列腺癌的生长几乎完全依赖于雄激素受体途径，大多数旨在阻断这一信号轴的疗法都是治疗该疾病的有效手段。不幸的是，这类疗法总是会失败，癌症会发展到雄激素非依赖阶段。在这种情况下，雄激素受体几乎总会发生突变，且有大量证据表明肿瘤会持续生长。受体被认为保持活性的一种机制是突变。本文综述了雄激素受体突变后肿瘤生长的分子机制以及一些有前景的前列腺癌治疗原则和全身化疗方案。
