Shimazaki J, Akakura K, Furuya Y, Ito H
Department of Urology, School of Medicine, Chiba University.
Nihon Rinsho. 1997 May;55(5):1143-8.
Eighty percent of prostate cancer with metastasis respond to androgen ablasion, showing initial androgen-sensitive growth. However, more than half of responders gradually loses dependency up to 5 years. Animal experiments reveal that loss of androgen sensitivity is attributable to complex reasons; adaptation, paracrine control by other androgen-independent tissues, genetic changes and mutation of androgen receptor. Most important event is explained from alteration of expression on oncogenes and suppressor genes. Counterplan of the progression was discussed.
80%发生转移的前列腺癌对雄激素剥夺有反应，表现出初始的雄激素敏感性生长。然而，超过一半的反应者在5年内会逐渐失去依赖性。动物实验表明，雄激素敏感性丧失归因于复杂的原因；包括适应性、其他雄激素非依赖性组织的旁分泌控制、基因变化以及雄激素受体的突变。最重要的事件可从癌基因和抑癌基因表达的改变来解释。文中还讨论了针对该进展的应对方案。
