健康年轻成年人中25-羟基维生素D与骨密度峰值及身体成分之间的关系。
The relation between 25-hydroxyvitamin D with peak bone mineral density and body composition in healthy young adults.
作者信息
Boot Annemieke M, Krenning Eric P, de Muinck Keizer-Schrama Sabine M P F
机构信息
Division of Endocrinology, Department of Pediatrics, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.
出版信息
J Pediatr Endocrinol Metab. 2011;24(5-6):355-60. doi: 10.1515/jpem.2011.052.
OBJECTIVE
The associations between peak bone mineral density (BMD) and body composition with 25 hydroxyvitamin D (25OHD) levels in healthy young adults were evaluated.
METHODS
The number of participants was 464; 347 women and 117 men. The mean age was 24.3 years (range 17-31 years). BMD of the lumbar spine, total body and femoral neck (FN) and body composition were measured by dual energy X-ray absorptiometry. Volumetric BMD, bone mineral apparent density (BMAD), of the lumbar spine and FN was calculated.
RESULTS
In females, 25OHD level was positively associated with FN BMD and BMAD (both p<0.01) and negatively with percentage body fat (p<0.001). In males, 25OHD levels had a positive association with total body BMD and lean body mass (p=0.03 and p=0.01).
CONCLUSIONS
25OHD level is a determinant of peak BMD in both sexes. Vitamin D status was associated with body fat in females and with lean body mass in males.
目的
评估健康年轻成年人的峰值骨密度（BMD）和身体成分与25羟维生素D（25OHD）水平之间的关联。
方法
参与者有464人，其中347名女性和117名男性。平均年龄为24.3岁（范围17 - 31岁）。采用双能X线吸收法测量腰椎、全身和股骨颈（FN）的骨密度以及身体成分。计算腰椎和FN的体积骨密度、骨矿物质表观密度（BMAD）。
结果
在女性中，25OHD水平与FN骨密度和BMAD呈正相关（均p<0.01），与体脂百分比呈负相关（p<0.001）。在男性中，25OHD水平与全身骨密度和瘦体重呈正相关（p = 0.03和p = 0.01）。
结论
25OHD水平是男女峰值骨密度的一个决定因素。维生素D状态在女性中与体脂有关，在男性中与瘦体重有关。
Zotero 插件