Department of Anesthesiology, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Department of Anesthesiology, Chi Mei Medical Center, Tainan 71004, Taiwan.
Nutrients. 2022 Aug 29;14(17):3556. doi: 10.3390/nu14173556.
Background: This study was conducted to evaluate associations between bone mineral density (BMD) and four selected circulating nutrients, particularly vitamin C, among adults aged 20−49 years. Methods: In this retrospective cross-sectional study, the lumbar spine BMD of 866 men and 589 women were measured by dual-energy X-ray absorptiometry and divided into tertiles, respectively. Logistic regressions were used to identify the predictors of low BMD by comparing subjects with the highest BMD to those with the lowest. Results: Multivariate logistic regressions identified suboptimal plasma vitamin C (adjusted odds ratio (AOR) 1.64, 95% confidence interval (CI) 1.16, 2.31), suboptimal serum vitamin B12 (AOR 2.05, 95% CI 1.02, 4.12), and low BMI (BMI < 23) (AOR 1.68, 95% CI 1.12, 2.53) as independent predictors for low BMD in men. In women, low BMI was the only independent predictor for low BMD. Plasma vitamin C, categorized as suboptimal (≤8.8 mg/L) and sufficient (>8.8 mg/L), was positively significantly correlated with the lumbar spine BMD in men, but there was no association in women. Conclusions: Plasma vitamin C, categorized as suboptimal and sufficient, was positively associated with the lumbar spine BMD in young and early middle-aged men. A well-designed cohort study is needed to confirm the findings.
本研究旨在评估 20-49 岁成年人的骨密度（BMD）与四种循环营养素（尤其是维生素 C）之间的关联。
在这项回顾性横断面研究中，通过双能 X 射线吸收法测量了 866 名男性和 589 名女性的腰椎 BMD，并分别将其分为三分位。通过将最高 BMD 的受试者与最低 BMD 的受试者进行比较，使用逻辑回归来确定低 BMD 的预测因素。
多变量逻辑回归确定了血浆维生素 C 不足（调整后的优势比（AOR）为 1.64，95%置信区间（CI）为 1.16，2.31）、血清维生素 B12 不足（AOR 为 2.05，95%CI 为 1.02，4.12）和低 BMI（BMI<23）（AOR 为 1.68，95%CI 为 1.12，2.53）是男性低 BMD 的独立预测因素。在女性中，低 BMI 是低 BMD 的唯一独立预测因素。血浆维生素 C 分为不足（≤8.8mg/L）和充足（>8.8mg/L），与男性的腰椎 BMD 呈正显著相关，但在女性中没有关联。
血浆维生素 C，分类为不足和充足，与年轻和中年早期男性的腰椎 BMD 呈正相关。需要进行精心设计的队列研究来证实这些发现。
