Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
DNA Cell Biol. 2012 Mar;31(3):337-41. doi: 10.1089/dna.2011.1334. Epub 2011 Aug 8.
Glutathione S-transferases class zeta (GSTζ) is involved in the detoxification of xenobiotic compounds and catalyzes the biotransformation of a variety of α-haloacids including dichloroacetic acid and chlorofluoroacetic acid. It has been reported that, in mice, deficiency of Gstz1 (a member of GSTζ) resulted in the generation of a constant level of oxidative stress. The present study was carried out to investigate the association between genetic polymorphisms of GSTZ1 (in promoter site G-1002A and in coding sites Glu32Lys and Gly42Arg) and risk of breast cancer. We included 106 females with breast cancer and 106 healthy females frequency matched for age. The study polymorphisms were not associated with risk of breast cancer (p>0.05). The polymorphisms of GSTZ1 showed strong linkage disequilibrium among cancer patients and control subjects (p<0.0001). There was no significant difference between cancer patients and controls for frequencies of the GSTZ1 haplotypes (p>0.05). It seems there is no meaningful relationship between the genetic polymorphisms of GSTZ1 and risk of breast cancer.
谷胱甘肽 S-转移酶 ζ 类（GSTζ）参与外来化合物的解毒，并催化各种α-卤代酸的生物转化，包括二氯乙酸和氯氟乙酸。据报道，在小鼠中，Gstz1（GSTζ 的一个成员）的缺乏导致氧化应激水平的持续产生。本研究旨在探讨 GSTZ1（启动子位点 G-1002A 和编码位点 Glu32Lys 和 Gly42Arg）的遗传多态性与乳腺癌风险之间的关系。我们纳入了 106 名女性乳腺癌患者和 106 名年龄匹配的健康女性作为对照组。研究表明，这些多态性与乳腺癌风险无关（p>0.05）。在癌症患者和对照组中，GSTZ1 的多态性之间存在很强的连锁不平衡（p<0.0001）。癌症患者和对照组之间 GSTZ1 单倍型的频率没有显著差异（p>0.05）。因此，GSTZ1 的遗传多态性与乳腺癌风险之间似乎没有有意义的关系。
