Department of Obstetrics and Gynecology, Jean Verdier Hospital, AP-HP, avenue du 14 Juillet, Bondy 93143, University Paris XIII, Bobigny, France.
Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):122-6. doi: 10.1016/j.ejogrb.2011.07.004. Epub 2011 Aug 6.
The aim of this study was to assess and validate a management protocol for infertile patients affected by at least one hydrosalpinx.
Eighty-one consecutive infertile normo-ovulatory patients with uni or bilateral hydrosalpinx planed to be surgically managed were included in the protocol from November 2003 to May 2007. During laparoscopy, a systematic evaluation of the tubes was firstly conducted and the local management protocol based on validated tubal prognostic scores was applied. Surgery for hydrosalpinx was either conservative by neosalpingostomy or radical by salpingectomy. The primary end-point was the cumulative clinical pregnancy rate.
115 hydrosalpinges out of 153 present tubes were confirmed during laparoscopy. Neosalpingostomy was possible in 35 patients featuring 50 hydrosalpinges (43.2% and 43.5%, respectively). Salpingectomy was necessary for the others (46 patients representing 65 hydrosalpinges). The mean follow-up period was 31.8 ± 12.4 months. The overall cumulative pregnancy rate was 61% per couple who completed the protocol (33/54 patients). The cumulative pregnancy rate was 50% after IVF in patients who underwent bilateral salpingectomy. Among patients with at least one functional tube, the overall cumulative pregnancy rate was 63.3%, with a spontaneous pregnancy rate of 30.4%.
Hydrosalpinx management can be conservative with a tubal conservative of 43.5% and fair chances for spontaneous conception. An integrated management of hydrosalpinx including ART actually leads to a cumulative pregnancy rate of 61% per patient.
本研究旨在评估和验证一种针对至少单侧输卵管积水的不孕患者的管理方案。
2003 年 11 月至 2007 年 5 月,81 例连续的单侧或双侧输卵管积水且计划手术治疗的正常排卵不孕患者纳入该方案。在腹腔镜检查期间,首先对输卵管进行系统评估,并应用基于经过验证的输卵管预后评分的局部管理方案。输卵管积水的手术治疗方式为输卵管造口术(保守治疗)或输卵管切除术(根治性治疗)。主要终点为累积临床妊娠率。
腹腔镜检查时确认 153 根输卵管中存在 115 根输卵管积水。35 例患者可行输卵管造口术,其中 50 根输卵管积水(分别为 43.2%和 43.5%)。其余患者需要进行输卵管切除术(46 例,65 根输卵管积水)。平均随访时间为 31.8±12.4 个月。完成该方案的 54 例患者中,夫妇的总累积妊娠率为 61%(33/54 例)。双侧输卵管切除术患者行 IVF 后的累积妊娠率为 50%。在至少有一根功能正常的输卵管的患者中,总累积妊娠率为 63.3%,自然妊娠率为 30.4%。
输卵管积水的管理可以采用保守治疗,保留 43.5%的输卵管,并有较好的自然受孕机会。将输卵管积水的治疗与 ART 相结合实际上可使每位患者的累积妊娠率达到 61%。