The Ohio State University, Department of Veterinary Biosciences, 350 Veterinary Medicine Academic Building, 1900 Coffey Road, Columbus, OH 43210, USA.
Vet Pathol. 2012 Jan;49(1):224-35. doi: 10.1177/0300985811415709. Epub 2011 Aug 8.
Genetically engineered mice and rats are increasingly used as models for exploring disease progression and mechanisms. The full spectrum of anatomic, biochemical, and functional changes that develop in novel, genetically engineered mouse and rat lines must be cataloged before predictions regarding the significance of the mutation may be extrapolated to diseases in other vertebrate species, including humans. A growing list of reference materials, including books, journal articles, and websites, has been produced in the last 2 decades to assist researchers in phenotyping newly engineered rodent lines. This compilation provides an extensive register of materials related to the pathology component of rodent phenotypic analysis. In this article, the authors annotate the resources they use most often, to allow for quick determination of their relevance to research projects.
基因工程小鼠和大鼠越来越多地被用作探索疾病进展和机制的模型。在预测突变的意义可能外推到其他脊椎动物物种（包括人类）的疾病之前，必须对新型基因工程小鼠和大鼠系中出现的所有解剖学、生化和功能变化进行编目。在过去的 20 年中，已经产生了越来越多的参考资料，包括书籍、期刊文章和网站，以帮助研究人员对新工程化的啮齿动物品系进行表型分析。本汇编提供了与啮齿动物表型分析的病理学组成部分相关的大量材料登记册。在本文中，作者对他们最常使用的资源进行了注释，以便快速确定它们与研究项目的相关性。
