丙硫氧嘧啶治疗 Graves 甲亢对颈动脉内膜中层厚度的消退作用。

Regression of the carotid intima media thickness by propylthiouracil therapy in Graves' hyperthyroidism.

机构信息

Department of Internal Medicine, School of Medicine, Zonguldak Karaelmas University, Turkey.

出版信息

Am J Med Sci. 2012 Apr;343(4):273-6. doi: 10.1097/MAJ.0b013e31822a8284.

DOI:10.1097/MAJ.0b013e31822a8284

PMID:21825964

Abstract

INTRODUCTION

One of the cardiovascular effects of hyperthyroidism is increased carotid intima media thickness (CIMT). The aim of this study is to investigate the CIMT in patients with Graves' hyperthyroidism and the effect of propylthiouracil (PTU) therapy on CIMT.

METHOD

Twenty-six patients with Graves' hyperthyroidism and 33 healthy controls were included in the study. CIMT was measured at the right and left external carotid arteries in every patient in both groups. CIMT was measured before and after the PTU therapy in patients with Graves' hyperthyroidism.

RESULTS

There was a significant difference in CIMT between the group of Graves' hyperthyroid patients and the control group (0.72 versus 0.55 mm, P < 0.0001) at baseline. Twenty-five of 26 patients with Graves' disease were followed up for 18 months prospectively. Euthyroidism has been achieved in 21 patients. After 18 months of treatment, CIMT decreased significantly compared with the baseline values [0.84 (0.54-1.3) to 0.72 (0.50-1.2), change 0.12 mm, P < 0.001].

CONCLUSION

Graves' hyperthyroidism is associated with atherosclerosis as assessed by CIMT. Treatment of Graves' hyperthyroidism with PTU decreases the CIMT.

摘要

简介

甲状腺功能亢进症的心血管效应之一是颈动脉内膜中层厚度（CIMT）增加。本研究旨在探讨格雷夫斯病甲亢患者的 CIMT 及丙基硫氧嘧啶（PTU）治疗对 CIMT 的影响。

方法

将 26 例格雷夫斯病甲亢患者和 33 例健康对照者纳入研究。两组患者均测量右侧和左侧颈外动脉的 CIMT。对格雷夫斯病甲亢患者在 PTU 治疗前后测量 CIMT。

结果

基线时格雷夫斯病甲亢组与对照组的 CIMT 差异有统计学意义（0.72 比 0.55mm，P<0.0001）。26 例格雷夫斯病患者中有 25 例前瞻性随访 18 个月。21 例患者达到甲状腺功能正常。治疗 18 个月后，CIMT 与基线值相比显著降低[0.84（0.54-1.3）至 0.72（0.50-1.2），变化 0.12mm，P<0.001]。