Queen's Medical Center, Nottingham University Hospitals, Nottingham, UK.
Neurocrit Care. 2011 Sep;15(2):298-301. doi: 10.1007/s12028-011-9596-6.
Statins were shown to have neuroprotective effects, with reduced vasospasm and delayed ischemic deficits in statin-treated patients after aneurysmal subarachnoid hemorrhage in two small, randomized, controlled clinical trials published in 2005. This review consolidated data from available published studies evaluating statin treatment for subarachnoid hemorrhage. A literature search was conducted to identify original research studies published through October 2010 testing immediate treatment with a statin in statin-naïve patients following aneurysmal SAH. Six randomized controlled clinical trials and four observational studies were identified. Despite inconsistent results among studies, a meta-analysis of randomized controlled data showed a significant reduction in delayed ischemic deficits with statins. Effect on vasospasm was more difficult to determine, due to differences in definitions used among studies. Interpretations from observational studies were limited by the use of relatively small sample sizes, historical controls, and treatment variability.
他汀类药物具有神经保护作用，在 2005 年发表的两项小型随机对照临床试验中，接受他汀类药物治疗的动脉瘤性蛛网膜下腔出血患者的血管痉挛减少，缺血性损伤延迟。本综述整合了现有评估他汀类药物治疗蛛网膜下腔出血的研究数据。通过文献检索，确定了截至 2010 年 10 月发表的评估他汀类药物治疗动脉瘤性蛛网膜下腔出血的他汀类药物治疗的原始研究。共确定了 6 项随机对照临床试验和 4 项观察性研究。尽管研究结果不一致，但对随机对照数据的荟萃分析显示，他汀类药物治疗可显著减少缺血性损伤延迟。由于研究中使用的定义不同，血管痉挛的影响更难确定。由于使用相对较小的样本量、历史对照和治疗变异性，观察性研究的解释受到限制。
