Wu Rui-Zhi, Zhang Jun-Ran, Qiu Chang-Jian, Meng Ya-Jing, Zhu Hong-Ru, Gong Qi-Yong, Huang Xiao-Qi, Zhang Wei
Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 May;42(3):397-400.
To explore the pathogenesis of posttraumatic stress disorder (PTSD) by studying default mode network during the resting state in patients with PTSD after homologous traumatic experience.
Seventeen PTSD patients and 20 matched normal controls received the examnation of resting-state fMRI scanning. Left and right posterior cingulate cortex was regarded as seed region respectively, and the functional connectivity about whole brain was assessed by using resting-state functional connectivity analysis.
Compared with control group, the patients with PTSD showed that the brain area with decreased functional connectivity included left superior frontal gyrus and right fusiform gyrus, while the brain area with increased functional connectivity included right precuneus, right superior temporal gyrus and right middle temporal gyrus.
The brain default mode network of PTSD patients is abnormal in resting state. These abnormalities might be the neuropathological mechanisms of PTSD.
通过研究经历同源创伤事件的创伤后应激障碍（PTSD）患者静息状态下的默认模式网络，探讨PTSD的发病机制。
17例PTSD患者和20例匹配的正常对照者接受静息态功能磁共振成像（fMRI）扫描检查。分别将左右后扣带回皮质作为种子区，采用静息态功能连接分析评估全脑功能连接。
与对照组相比，PTSD患者功能连接降低的脑区包括左侧额上回和右侧梭状回，而功能连接增加的脑区包括右侧楔前叶、右侧颞上回和右侧颞中回。
PTSD患者的脑默认模式网络在静息状态下存在异常。这些异常可能是PTSD的神经病理机制。
