Forestier F, Daffos F, Said R, Brunet C M, Guillaume P N
Service de Médecine et de Biologie foetales, Institut de Puériculture de Paris.
J Gynecol Obstet Biol Reprod (Paris). 1990;19(2):171-5.
Until now, transplacental passage of fluoride could only be checked during delivery. Recent developments in fetal blood sampling techniques in utero have made it possible to study its passage in pregnancy. Two tablets of 2.212 mg of sodium fluoride (Zymafluor) were given to 11 women with an average age of 27 1/2 years whose pregnancies on an average had lasted 22 weeks. They were having prenatal diagnosis by ultrasound guided fetal blood sampling in any case. The levels of fluoride were measured by the use of a specific electrode before the mother took fluoride and 40 minutes after she had taken it in both maternal and fetal blood samples. The results were compared with a controlled group of 11 pregnant women with similar characteristics: maternal age, duration of pregnancy and basal maternal fluoride levels. Fetal blood levels of fluorides in mothers who had taken sodium fluoride was statistically higher than in the controlled group (2.6 mumol/l and less than 1 mumol/l); this demonstrates in a statistically significant way that fluoride passes across the placenta in the fifth and sixth months of pregnancy which is the time when the milk teeth start to develop in the uterus.
到目前为止，氟化物的经胎盘传递只能在分娩时进行检测。子宫内胎儿采血技术的最新进展使得研究其在孕期的传递成为可能。给11名平均年龄为27.5岁、平均怀孕22周的女性服用两片2.212毫克的氟化钠（Zymafluor）。无论如何，她们都在接受超声引导下的胎儿采血进行产前诊断。在母亲服用氟化物之前以及服用后40分钟，使用特定电极测量母体和胎儿血样中的氟化物水平。将结果与11名具有相似特征的孕妇对照组进行比较：产妇年龄、怀孕时长和母体基础氟化物水平。服用氟化钠的母亲的胎儿血氟水平在统计学上高于对照组（分别为2.6微摩尔/升和低于1微摩尔/升）；这在统计学上显著表明，在怀孕的第五和第六个月，即乳牙在子宫内开始发育的时候，氟化物会穿过胎盘。
