Spivak J L
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218.
Int J Cell Cloning. 1990 Jan;8 Suppl 1:211-24; discussion 224-6. doi: 10.1002/stem.5530080720.
The currently available radioimmunoassay for erythropoietin (Epo) using recombinant reagents is an accurate, reproducible, sensitive and specific assay which can be used to identify whether lack of Epo is contributing to anemia and, by extension, whether therapy with recombinant Epo might be appropriate. Elevation of the serum Epo level with anemia suggests that a marrow abnormality is the cause of the anemia, while a "high" Epo level in a non-anemic or plethoric patient suggests the presence of hypoxia or autonomous Epo production. Liver disease can elevate the serum Epo level, while modest degrees of anemia do not affect it appreciably. The lowest Epo levels occur in polycythemia vera, but in a particular patient this finding is not completely diagnostic.
目前可用的使用重组试剂的促红细胞生成素（Epo）放射免疫测定法是一种准确、可重复、灵敏且特异的测定方法，可用于确定Epo缺乏是否导致贫血，进而确定重组Epo治疗是否合适。贫血时血清Epo水平升高提示骨髓异常是贫血的原因，而非贫血或红细胞增多患者的“高”Epo水平提示存在缺氧或Epo自主产生。肝脏疾病可使血清Epo水平升高，而轻度贫血对其影响不大。真性红细胞增多症时Epo水平最低，但在特定患者中这一发现并不完全具有诊断意义。
