Golde D W
Department of Medicine, UCLA School of Medicine 90024-1678.
Int J Cell Cloning. 1990 Jan;8 Suppl 1:4-10. doi: 10.1002/stem.5530080702.
The hematopoietic growth factors are a family of glycoprotein hormones that regulate hematopoietic cell proliferation and mature blood cell function. The list of colony-stimulating factors and interleukins known to stimulate blood cell production is now quite long; these hormones are produced in quantity by recombinant molecular methodologies and most have entered clinical trials. We will shortly have the power to regulate the numbers and function of the circulating blood cells, and the challenge of the coming decade will be in dissecting how these growth factors can be used optimally in therapeutic practice. A central theme of their use will be the enhancement of host defense, opening an area of medical therapy of great potential to reduce the morbidity and mortality of cancer, infectious diseases and immune deficiency states.
造血生长因子是一类糖蛋白激素，可调节造血细胞增殖和成熟血细胞功能。已知能刺激血细胞生成的集落刺激因子和白细胞介素种类如今相当多；这些激素通过重组分子方法大量生产，且大多数已进入临床试验阶段。我们很快就能调控循环血细胞的数量和功能，而未来十年的挑战将在于剖析如何在治疗实践中最佳地利用这些生长因子。其应用的一个核心主题将是增强宿主防御，从而开辟一个具有巨大潜力的医学治疗领域，以降低癌症、传染病和免疫缺陷状态的发病率和死亡率。
