Fackler M J, Strauss L C
Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland.
Hematol Oncol Clin North Am. 1990 Aug;4(4):849-65.
The interrelationship between proliferation, differentiation, and activation responses of hematopoietic progenitor cells and mature blood cells is complex. Therefore, we are only now learning what role colony-stimulating factors play in the regulation of normal hematopoiesis in vivo and in the dysregulation of hematopoiesis in leukemia. Recent advantages in molecular hematology have opened the door to the therapeutic administration of recombinant growth factors. Through continued preclinical trials in animals and by clinical trials in humans, a better understanding of the precise target cells and mechanisms of action of hematopoietic growth factors will improve the therapeutic index of administering colony-stimulating factors. Better understanding of hematopoietic growth factors will, in turn, suggest novel approaches to therapy of acute lymphoblastic leukemia.
造血祖细胞和成熟血细胞的增殖、分化及激活反应之间的相互关系是复杂的。因此，我们直到现在才了解集落刺激因子在体内正常造血调节及白血病造血失调中所起的作用。分子血液学领域的最新进展为重组生长因子的治疗性应用打开了大门。通过在动物身上持续进行的临床前试验以及在人类身上开展的临床试验，对造血生长因子的精确靶细胞和作用机制有更深入的了解将提高应用集落刺激因子的治疗指数。反过来，对造血生长因子的更好理解将为急性淋巴细胞白血病的治疗提出新的方法。
