用 Sox17 重返青春。
Return to youth with Sox17.
机构信息
Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA.
出版信息
Genes Dev. 2011 Aug 1;25(15):1557-62. doi: 10.1101/gad.17328611.
Abstract
Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this issue of Genes & Development, He and colleagues (pp. 1613-1627) show that overexpression of Sox17 can convert adult multipotential progenitors to self-renewing HSCs that possess fetal properties. These findings challenge the irreversibility of hematopoietic development, and open up new perspectives to understand the different forms of HSC self-renewal at distinct stages of ontogeny and during transformation.
摘要
造血干细胞（HSCs）从胎儿到成人状态的成熟以及向祖细胞的分化被认为遵循单行道。在本期《基因与发育》中，He 和同事们（第 1613-1627 页）表明 Sox17 的过表达可以将成人多能祖细胞转化为具有胎儿特性的自我更新 HSCs。这些发现挑战了造血发育的不可逆性，并为理解在个体发生的不同阶段和转化过程中不同形式的 HSC 自我更新提供了新的视角。
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本文引用的文献
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Direct conversion of human fibroblasts to multilineage blood progenitors.人类成纤维细胞向多谱系造血祖细胞的直接转化。
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