芬兰青少年及其父母超重的代际传递：一项 16 年的随访研究。

Intergenerational transmission of overweight among Finnish adolescents and their parents: a 16-year follow-up study.

机构信息

Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

出版信息

Int J Obes (Lond). 2011 Oct;35(10):1289-94. doi: 10.1038/ijo.2011.150. Epub 2011 Aug 9.

DOI:10.1038/ijo.2011.150

PMID:21829157

Abstract

OBJECTIVE

Previous studies have shown strong parental influences on adolescent overweight. However, longitudinal data is scarce on gender-specific effects of parental body mass index (BMI) on offspring overweight. The objective of this study was to examine the associations of parental pre-pregnancy BMI, weight change, BMI and BMI class transition 16 years after pregnancy with the BMI of their 16-year-old children.

SUBJECTS AND METHODS

The study population was derived from the general population-based Northern Finland Birth Cohort 1986. A total of 4788 child-mother-father trios (2325 boys, 2463 girls) were analysed. Weight and height of the adolescents were measured and overweight and obesity defined according to the International Obesity Task Force. For the parents, self-reported data were obtained and overweight and obesity defined according to the World Health Organization. Associations of parental BMI status and weight change with offspring BMI were assessed using binary logistic regression analyses stratified by gender and adjusted for parental age and education.

RESULTS

Children whose both parents were overweight or obese both before pregnancy and after 16-year follow-up had a strikingly high risk of overweight at age 16 years (boys odds ratio (OR) 5.66 95% confidence interval (CI) 3.12, 10.27; girls OR 14.84 95% CI 7.41, 29.73). Parental pre-pregnancy obesity strongly predicted offspring overweight (mother-son OR 4.36 95% CI 2.50, 7.59; mother-daughter OR 3.95 95% CI 2.34, 6.68; father-son OR 3.17 95% CI 1.70, 5.92; father-daughter OR 5.58 95% CI 3.09, 10.07).

CONCLUSION

Parental overweight conveys a major risk for overweight in children for which both parents' long-term overweight (BMI ≥25 kg m(-2) before pregnancy and after 16-year follow-up) was the strongest single predictor. Preventing intergenerational transmission of obesity by helping parents to maintain a healthy weight is an essential target for public health.

摘要

目的

先前的研究表明，父母对青少年超重有很大的影响。然而，关于父母体重指数（BMI）对后代超重的性别特异性影响的纵向数据很少。本研究的目的是检查父母孕前 BMI、体重变化、16 年后的 BMI 和 BMI 类别变化与 16 岁子女 BMI 的关系。

受试者和方法

研究人群来自基于人群的芬兰北部出生队列 1986。共分析了 4788 个母子-父子三人组（2325 名男孩，2463 名女孩）。青少年的体重和身高进行了测量，超重和肥胖按照国际肥胖工作组的标准定义。对于父母，通过自我报告获得数据，超重和肥胖按照世界卫生组织的标准定义。使用二元逻辑回归分析按性别分层，调整父母年龄和教育，评估父母 BMI 状况和体重变化与子女 BMI 的关系。

结果

父母双方在孕前和 16 年随访后均超重或肥胖的儿童，16 岁时超重的风险极高（男孩比值比（OR）5.66，95%置信区间（CI）3.12，10.27；女孩 OR 14.84，95% CI 7.41，29.73）。父母孕前肥胖强烈预测子女超重（母亲-儿子 OR 4.36，95% CI 2.50，7.59；母亲-女儿 OR 3.95，95% CI 2.34，6.68；父亲-儿子 OR 3.17，95% CI 1.70，5.92；父亲-女儿 OR 5.58，95% CI 3.09，10.07）。