Kuboi H, Mizoguchi Y, Kawada N, Sakaguchi H, Seki S, Kobayashi K, Morisawa S
Third Department of Internal Medicine, Osaka City University Medical School.
Nihon Shokakibyo Gakkai Zasshi. 1990 Feb;87(2):211-7.
When heat-killed Propionibacterium acnes was intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide (LPS) was also intravenously injected, most of them died of massive hepatic cell necrosis. However, then glucagon (0.5 mg/kg body weight) and insulin (0.5 units/kg body weight) or glucagon (0.5 mg/kg body weight) individually were administered during this experimental induction of massive hepatic cell necrosis, the survival rate of mice increased and serum transaminase levels improved. Also, the histological changes of the liver improved remarkably. But, insulin (0.5 units/kg body weight) individually was not effective in an experimental massive cell necrosis model. These results suggested that glucagon and insulin was effective in our experimental massive hepatic cell necrosis model.
当将热灭活的痤疮丙酸杆菌静脉注射到小鼠体内，7天后再静脉注射少量革兰氏阴性脂多糖（LPS）时，大多数小鼠死于大规模肝细胞坏死。然而，在这种实验性大规模肝细胞坏死诱导过程中，单独给予胰高血糖素（0.5毫克/千克体重）和胰岛素（0.5单位/千克体重）或单独给予胰高血糖素（0.5毫克/千克体重）后，小鼠的存活率提高，血清转氨酶水平改善。此外，肝脏的组织学变化也有明显改善。但是，单独给予胰岛素（0.5单位/千克体重）在实验性大规模细胞坏死模型中无效。这些结果表明，胰高血糖素和胰岛素在我们的实验性大规模肝细胞坏死模型中是有效的。
