Mizoguchi Y, Tsutsui H, Miyajima K, Sakagami Y, Seki S, Kobayashi K, Yamamoto S, Morisawa S
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Hepatology. 1987 Nov-Dec;7(6):1184-8. doi: 10.1002/hep.1840070603.
When a small amount of Gram-negative lipopolysaccharide was intravenously injected into mice which had been injected with heat-killed Propionibacterium acnes 7 days before, massive hepatic cell necrosis was induced and most of the mice died 24 hr later. However, when prostaglandin E1 was administered with lipopolysaccharide, remarkable improvements in the survival rate and in the histological changes of the liver were observed. In order to find out how prostaglandin E1 suppressed the induction of massive hepatic cell necrosis in this experimental model, we studied the effects of prostaglandin E1 on the activation of liver adherent cells, from which the cytotoxic factor is released, and on the protection of hepatocytes from the cytotoxic factor. As a result, prostaglandin E1 not only inhibited the activation of liver adherent cells and suppressed the release of the cytotoxic factor, but it also directly affected the hepatocytes and protected them from the cytotoxic factor.
当向7天前已注射热灭活痤疮丙酸杆菌的小鼠静脉内注射少量革兰氏阴性脂多糖时，会诱导大量肝细胞坏死，并且大多数小鼠在24小时后死亡。然而，当前列腺素E1与脂多糖一起给药时，观察到存活率和肝脏组织学变化有显著改善。为了弄清楚前列腺素E1在该实验模型中如何抑制大量肝细胞坏死的诱导，我们研究了前列腺素E1对肝脏黏附细胞（释放细胞毒性因子的细胞）活化的影响以及对肝细胞免受细胞毒性因子影响的保护作用。结果，前列腺素E1不仅抑制肝脏黏附细胞的活化并抑制细胞毒性因子的释放，而且还直接影响肝细胞并保护它们免受细胞毒性因子的影响。
