瑜伽对早期可手术乳腺癌手术患者术后结局及伤口愈合的影响。
Influence of yoga on postoperative outcomes and wound healing in early operable breast cancer patients undergoing surgery.
作者信息
Rao Raghavendra M, Nagendra H R, Raghuram Nagarathna, Vinay C, Chandrashekara S, Gopinath K S, Srinath B S
出版信息
Int J Yoga. 2008 Jan;1(1):33-41. doi: 10.4103/0973-6131.36795.
CONTEXT
Pre- and postoperative distress in breast cancer patients can cause complications and delay recovery from surgery.
OBJECTIVE
The aim of our study was to evaluate the effects of yoga intervention on postoperative outcomes and wound healing in early operable breast cancer patients undergoing surgery.
METHODS
Ninety-eight recently diagnosed stage II and III breast cancer patients were recruited in a randomized controlled trial comparing the effects of a yoga program with supportive therapy and exercise rehabilitation on postoperative outcomes and wound healing following surgery. Subjects were assessed at the baseline prior to surgery and four weeks later. Sociodemographic, clinical and investigative notes were ascertained in the beginning of the study. Blood samples were collected for estimation of plasma cytokines-soluble Interleukin (IL)-2 receptor (IL-2R), tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. Postoperative outcomes such as the duration of hospital stay and drain retention, time of suture removal and postoperative complications were ascertained. We used independent samples t test and nonparametric Mann Whitney U tests to compare groups for postoperative outcomes and plasma cytokines. Regression analysis was done to determine predictors for postoperative outcomes.
RESULTS
Sixty-nine patients contributed data to the current analysis (yoga: n = 33, control: n = 36). The results suggest a significant decrease in the duration of hospital stay (P = 0.003), days of drain retention (P = 0.001) and days for suture removal (P = 0.03) in the yoga group as compared to the controls. There was also a significant decrease in plasma TNF alpha levels following surgery in the yoga group (P < 0.001), as compared to the controls. Regression analysis on postoperative outcomes showed that the yoga intervention affected the duration of drain retention and hospital stay as well as TNF alpha levels.
CONCLUSION
The results suggest possible benefits of yoga in reducing postoperative complications in breast cancer patients.
背景
乳腺癌患者术前和术后的痛苦会引发并发症并延缓手术康复。
目的
我们研究的目的是评估瑜伽干预对接受手术的早期可手术乳腺癌患者术后结局及伤口愈合的影响。
方法
98例新诊断的II期和III期乳腺癌患者被纳入一项随机对照试验，比较瑜伽项目与支持性治疗及运动康复对术后结局和术后伤口愈合的影响。在手术前的基线期和四周后对受试者进行评估。在研究开始时确定社会人口统计学、临床和调查记录。采集血样以测定血浆细胞因子可溶性白细胞介素（IL）-2受体（IL-2R）、肿瘤坏死因子（TNF）-α和干扰素（IFN）-γ。确定术后结局，如住院时间、引流管留置时间、拆线时间和术后并发症。我们使用独立样本t检验和非参数曼-惠特尼U检验来比较各组的术后结局和血浆细胞因子。进行回归分析以确定术后结局的预测因素。
结果
69例患者为当前分析提供了数据（瑜伽组：n = 33，对照组：n = 36）。结果表明，与对照组相比，瑜伽组的住院时间（P = 0.003）、引流管留置天数（P = 0.001）和拆线天数（P = 0.03）显著减少。与对照组相比，瑜伽组术后血浆TNF-α水平也显著降低（P < 0.001）。对术后结局的回归分析表明，瑜伽干预影响引流管留置时间、住院时间以及TNF-α水平。
结论
结果表明瑜伽可能有助于减少乳腺癌患者的术后并发症。
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