School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.
PLoS One. 2011;6(7):e23017. doi: 10.1371/journal.pone.0023017. Epub 2011 Jul 28.
Damage to the parietal lobe can induce a condition known as spatial neglect, characterized by a lack of awareness of the personal and/or extrapersonal space opposite the damaged brain region. Spatial neglect is commonly assessed clinically using either the line bisection or the target cancellation task. However, it is unclear whether poor performance on each of these two tasks is associated with the same or different lesion locations. To date, methodological limitations and differences have prevented a definitive link between task performance and lesion location to be made. Here we report findings from a voxel-based lesion symptom mapping (VLSM) analysis of an unbiased selection of 44 patients with a recent unifocal stroke. Patients performed both the line bisection and target cancellation task. For each of the two tasks a continuous score was incorporated into the VLSM analysis. Both tasks correlated highly with each other (r = .76) and VLSM analyses indicated that the angular gyrus was the critical lesion site for both tasks. The results suggest that both tasks probe the same underlying cortical deficits and although the cancellation task was more sensitive than the line bisection task, both can be used in a clinical setting to test for spatial neglect.
顶叶损伤可导致一种称为空间忽略的病症，其特征是对损伤大脑区域相对的个人和/或体外空间缺乏意识。空间忽略通常使用线二分或目标取消任务在临床上进行评估。然而，这两种任务中的每一种表现不佳是否与相同或不同的病变部位相关尚不清楚。迄今为止，方法学上的局限性和差异使得无法在任务表现和病变部位之间建立明确的联系。在这里，我们报告了对 44 名近期单侧中风患者进行无偏选择的基于体素的病变症状映射（VLSM）分析的结果。患者执行了线二分和目标取消任务。对于这两个任务中的每一个，都将连续得分纳入 VLSM 分析。这两个任务彼此高度相关（r=0.76），VLSM 分析表明角回是这两个任务的关键病变部位。结果表明，这两个任务都探测到相同的潜在皮质缺陷，尽管取消任务比线二分任务更敏感，但都可以在临床环境中用于测试空间忽略。
