Stone O J
Med Hypotheses. 1990 Feb;31(2):161-4. doi: 10.1016/0306-9877(90)90013-5.
Neoplasms have extensive qualitative and quantitative changes in their extracellular matrix. Lytic factors from neoplasms breakdown extracellular matrix of the areas adjacent to the neoplasms and fibroblasts in these areas produce increased extracellular matrix. Some of the extracellular matrix fractions are normally present in serum. Multiple fractions derived from extracellular matrix are present in the serum of tumor patients. Tumor patients often have decreased early cellular inflammation and immunity. These reactions depend on a normal extracellular matrix. A number of known facts about the tumor bearing host can be explained by the concept that the host's generalized extracellular matrix is altered by circulating fractions of extracellular matrix. These could be qualitative or quantitative defects as well as an abundance of depolymerized fractions. The beneficial effects of cytokines, streptococcal infections and pyridoxine deficiency on tumors can be explained by this concept.
肿瘤在其细胞外基质中存在广泛的质和量的变化。肿瘤产生的溶解因子会破坏肿瘤邻近区域的细胞外基质，这些区域的成纤维细胞会产生更多的细胞外基质。一些细胞外基质成分正常情况下存在于血清中。来自细胞外基质的多种成分存在于肿瘤患者的血清中。肿瘤患者通常早期细胞炎症和免疫力会降低。这些反应依赖于正常的细胞外基质。关于荷瘤宿主的一些已知事实可以用这样的概念来解释，即宿主的全身细胞外基质会被循环中的细胞外基质成分改变。这些改变可能是质或量的缺陷，也可能是大量解聚成分。细胞因子、链球菌感染和维生素B6缺乏对肿瘤的有益作用都可以用这个概念来解释。
