Stone O J
Med Hypotheses. 1988 Mar;25(3):141-5. doi: 10.1016/0306-9877(88)90051-5.
It is known that at sites of acute inflammation there is increased ground substance formation and fibroblast proliferation. There is also increased serum glycoprotein following localized acute inflammation. The author proposes that a severe acute inflammatory response in a localized area of the body induces a generalized increase in ground substance viscosity (generalized ground substance adaptive phenomenon). This would increase host resistance to invasion and heighten the inflammatory response. There are multiple clinical and experimental facts which could be explained by this response. These include guttate psoriasis, pustular psoriasis, pustular bacterid of Andrew's, Reiter's syndrome, and others. This response would include some aspects of adjuvant disease. Increased generalized ground substance viscosity could also explain the beneficial effects of streptococcal cell fractions and streptococcal infections on tumor regression. A number of other clinical observations could be explained. Connective tissue-activating peptide released at the inflammation site could be having a systemic effect. It could be generally beneficial to have generalized increased ground substance viscosity when acute inflammation is occurring in a localized area. A few patients who already have a highly reactive inflammatory level could develop excess inflammation especially at sites of trauma, or preexisting inflammation.
已知在急性炎症部位，基质形成增加且成纤维细胞增殖。局部急性炎症后血清糖蛋白也会增加。作者提出，身体局部区域的严重急性炎症反应会导致基质粘度普遍增加（全身性基质适应性现象）。这将增加宿主对入侵的抵抗力并增强炎症反应。有多个临床和实验事实可以用这种反应来解释。这些包括点滴状银屑病、脓疱型银屑病、安德鲁脓疱型菌疹、赖特综合征等。这种反应将包括佐剂病的一些方面。全身性基质粘度增加也可以解释链球菌细胞成分和链球菌感染对肿瘤消退的有益作用。还可以解释许多其他临床观察结果。炎症部位释放的结缔组织活化肽可能具有全身作用。当局部区域发生急性炎症时，全身性基质粘度普遍增加通常可能是有益的。一些已经具有高反应性炎症水平的患者可能会出现过度炎症，尤其是在创伤部位或先前存在的炎症部位。
