Liu Jing-Jing, Wang Xin-Luan, Guo Bao-Lin, Huang Wen-Hua, Xiao Pei-Gen, Huang Chao-Qing, Zheng Li-Zhen, Zhang Ge, Qin Ling, Tu Guang-Zhong
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
J Asian Nat Prod Res. 2011 Sep;13(9):851-60. doi: 10.1080/10286020.2011.598858.
Two new triterpenoid saponins 1 and 2, along with six known saponins 3-8, were isolated from the roots of Dipsacus asper. The structures of new compounds were established as 3-O-β-d-glucopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 3)]-β-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranosyl-hederagenin-28-O-β-d-glucopyranoside (dipsacus saponin J, 1) and 3-O-α-l-arabinopyranosyl-hederagenin-28-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside (dipsacus saponin K, 2). The structures were determined by extensive analysis of their spectroscopic data. Compounds 6 and 7 could significantly stimulate UMR106 cell proliferation and increase alkaline phosphatase activities in UMR106 cell at the concentration of 4 μM.
从糙叶续断根中分离得到两个新的三萜皂苷1和2，以及六个已知皂苷3 - 8。新化合物的结构确定为3 - O - β - d - 吡喃葡萄糖基 - (1→4)-[α - l - 吡喃鼠李糖基 - (1→3)]-β - d - 吡喃葡萄糖基 - (1→3)-α - l - 吡喃鼠李糖基 - (1→2)-α - l - 吡喃阿拉伯糖基 - 常春藤皂苷元 - 28 - O - β - d - 吡喃葡萄糖苷（续断皂苷J，1）和3 - O - α - l - 吡喃阿拉伯糖基 - 常春藤皂苷元 - 28 - O - β - d - 吡喃葡萄糖基 - (1→6)-β - d - 吡喃葡萄糖基 - (1→6)-β - d - 吡喃葡萄糖苷（续断皂苷K，2）。通过对其光谱数据的广泛分析确定了结构。化合物6和7在浓度为4μM时可显著刺激UMR106细胞增殖并增加UMR106细胞中的碱性磷酸酶活性。
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