重度抑郁症的遗传蓝图：影像遗传学研究的贡献。
The genetic blueprint of major depressive disorder: contributions of imaging genetics studies.
机构信息
Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
出版信息
World J Biol Psychiatry. 2011 Oct;12(7):474-88. doi: 10.3109/15622975.2011.596220. Epub 2011 Aug 11.
OBJECTIVES
To review neuroimaging intermediate phenotypes of MDD and their relation to genetic risk variants.
METHODS
A systematic literature search of peer-reviewed English language articels using PubMed ( www.pubmed.org ) was performed.
RESULTS
Comprehensive evidence on the influence of serotonergic genes (SLC6A4, HTR1A, MAOA, TPH2) and BDNF on the following neural intermediate phenotypes is displayed: amygdala reactivity, coupling of amygdala-anterior cingulate cortex (ACC) activity, ACC volume, hippocampal volume and serotonin receptor 1A (5-HT1A) binding potential (BP).
CONCLUSIONS
Intermediate phenotypes may bridge the gap between genotype and phenotype by reducing the impreciseness of psychiatric phenotypes and yield more insights into the underlying biology.
目的
综述 MDD 的神经影像学中间表型及其与遗传风险变异的关系。
方法
使用 PubMed（www.pubmed.org）对同行评审的英文文献进行系统的文献检索。
结果
展示了关于 5-羟色胺能基因（SLC6A4、HTR1A、MAOA、TPH2）和脑源性神经营养因子（BDNF）对以下神经中间表型影响的综合证据：杏仁核反应性、杏仁核-前扣带皮层（ACC）活动耦合、ACC 体积、海马体积和 5-羟色胺受体 1A（5-HT1A）结合潜能（BP）。
结论
中间表型可以通过减少精神疾病表型的不精确性来缩小基因型和表型之间的差距，并为潜在生物学提供更多的见解。
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