Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
School of Psychology, Deakin University, Melbourne, Australia.
CNS Neurosci Ther. 2018 Nov;24(11):1020-1036. doi: 10.1111/cns.12829. Epub 2018 Feb 23.
Genetic-neuroimaging studies could identify new potential endophenotypes of major depressive disorder (MDD). Morphological and functional alterations may be attributable to genetic factors that regulate neurogenesis and neurodegeneration. Given that the association between gene polymorphisms and brain morphology or function has varied across studies, this systematic review aims at evaluating and summarizing all available genetic-neuroimaging studies. Twenty-eight gene variants were evaluated in 64 studies by structural or functional magnetic resonance imaging. Significant genetic-neuroimaging associations were found in monoaminergic genes, BDNF genes, glutamatergic genes, HPA axis genes, and the other common genes, which were consistent with common hypotheses of the pathogenesis of MDD.
遗传神经影像学研究可以确定重度抑郁症（MDD）的新的潜在的内表型。形态和功能的改变可能归因于调节神经发生和神经退行性变的遗传因素。鉴于基因多态性与大脑形态或功能之间的关联在不同的研究中存在差异，本系统综述旨在评估和总结所有可用的遗传神经影像学研究。通过结构或功能磁共振成像评估了 64 项研究中的 28 个基因变异。在单胺能基因、BDNF 基因、谷氨酸能基因、HPA 轴基因和其他常见基因中发现了显著的遗传神经影像学关联，这与 MDD 发病机制的常见假说一致。
