University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.
Curr Drug Deliv. 2011 Nov;8(6):622-33. doi: 10.2174/156720111797635559.
The purpose of writing this review on chronotherapeutic drug delivery systems (ChrDDs) is to review the literatures with special focus on ChrDDs and the various dosage forms, techniques that are used to target the circadian rhythms (CR) of various diseases. Many functions of the human body vary considerably in a day. ChrDDs refers to a treatment method in which in vivo drug availability is timed to match circadian rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. Several techniques have been developed but not many dosage forms for all the diseases are available in the market. ChrDDs are gaining importance in the field of pharmaceutical technology as these systems reduce dosing frequency, toxicity and deliver the drug that matches the CR of that particular disease when the symptoms are maximum to worse. Finally, the ultimate benefit goes to the patient due the compliance and convenience of the dosage form. Some diseases that follow circadian rhythms include cardiovascular diseases, asthma, arthritis, ulcers, diabetes etc. ChrDDs in the market were also discussed and the current technologies used to formulate were also stated. These technologies include Contin® , Chronotopic®, Pulsincaps®, Ceform®, Timerx®, Oros®, Codas®, Diffucaps®, Egalet®, Tablet in capsule device, Core-in-cup tablet technology. A coated drug-core tablet matrix, A bi-layered tablet, Multiparticulate-based chronotherapeutic drug delivery systems, Chronoset and Controlled release microchips.
本文撰写的目的是回顾时间治疗药物传递系统（ChrDDs）的文献，特别关注 ChrDDs 以及用于针对各种疾病的昼夜节律（CR）的各种剂型、技术。人体的许多功能在一天中变化很大。ChrDDs 是指一种治疗方法，其中体内药物的有效性与疾病的昼夜节律相匹配，以优化治疗效果并最大程度地减少副作用。已经开发了几种技术，但市场上并不是所有疾病都有相应的剂型。ChrDDs 在药物技术领域变得越来越重要，因为这些系统减少了给药频率、降低了毒性，并在疾病症状最严重时提供了与特定疾病的 CR 相匹配的药物。最终，由于剂型的顺应性和便利性，患者将从中受益。遵循昼夜节律的一些疾病包括心血管疾病、哮喘、关节炎、溃疡、糖尿病等。还讨论了市场上的 ChrDDs，并说明了用于配方的当前技术。这些技术包括 Contin®、Chronotopic®、Pulsincaps®、Ceform®、Timerx®、Oros®、Codas®、Diffucaps®、Egalet®、胶囊内片剂装置、核心杯片剂技术。包衣药物核心片剂基质、双层片剂、多颗粒基时间治疗药物传递系统、Chronoset 和控释微芯片。
