Dionísio Marita, Grenha Ana
CBME - Centre for Molecular and Structural Biomedicine/IBB - Institute for Biotechnology and Bioengineering, Faculty of Sciences and Technology, University of Algarve, Campus de Gambelas, Faro, Portugal.
J Pharm Bioallied Sci. 2012 Jul;4(3):175-85. doi: 10.4103/0975-7406.99013.
Polysaccharides have been finding, in the last decades, very interesting and useful applications in the biomedical and, specifically, in the biopharmaceutical field. Locust bean gum is a polysaccharide belonging to the group of galactomannans, being extracted from the seeds of the carob tree (Ceratonia siliqua). This polymer displays a number of appealing characteristics for biopharmaceutical applications, among which its high gelling capacity should be highlighted. In this review, we describe critical aspects of locust bean gum, contributing for its role in biopharmaceutical applications. Physicochemical properties, as well as strong and effective synergies with other biomaterials are described. The potential for in vivo biodegradation is explored and the specific biopharmaceutical applications are discussed.
在过去几十年中，多糖在生物医学领域，特别是生物制药领域有着非常有趣且有用的应用。刺槐豆胶是一种属于半乳甘露聚糖类的多糖，从角豆树（Ceratonia siliqua）的种子中提取。这种聚合物在生物制药应用中展现出许多吸引人的特性，其中其高凝胶能力值得特别强调。在本综述中，我们描述了刺槐豆胶的关键方面，阐述了其在生物制药应用中的作用。描述了其物理化学性质，以及与其他生物材料的强大而有效的协同作用。探讨了其体内生物降解的潜力，并讨论了具体的生物制药应用。
