Division of Cancer Medicine, Peter MacCallum Cancer Centre, The Royal Melbourne Hospital, Victoria, Australia.
Intern Med J. 2011 Aug;41(8):588-94. doi: 10.1111/j.1445-5994.2011.02544.x.
Mobilization and collection of haemopoietic stem and progenitor cells (HSPC) is the cornerstone of autologous and allogeneic stem cell transplantation for a wide variety of haematological and some non-haematological malignancies. Centres providing this service face the challenge of optimizing the likelihood of successful collection of transplantable doses of cells, while maximizing the efficiency of the apheresis unit and minimizing the risk of toxicity as well as mobilization failure. Recent developments in the understanding of the molecular mechanisms of mobilization have led to the emergence of novel strategies for HSPC mobilization, which may assist in meeting these imperatives. The task for clinicians is how to incorporate the use of these strategies into practice, in the light of emerging evidence for efficacy and safety of these agents. Herein, the literature is reviewed, and a proposed algorithm for HSPC mobilization is presented.
动员和采集造血干细胞和祖细胞（HSPC）是自体和异基因干细胞移植治疗多种血液系统恶性肿瘤和某些非血液系统恶性肿瘤的基石。提供这项服务的中心面临着优化成功采集可移植细胞剂量的可能性的挑战，同时最大限度地提高单采单位的效率，最大限度地降低毒性和动员失败的风险。对动员分子机制的理解的最新进展导致了新的 HSPC 动员策略的出现，这可能有助于满足这些要求。临床医生的任务是如何根据这些药物的疗效和安全性的新证据，将这些策略纳入实践。本文对文献进行了回顾，并提出了一个 HSPC 动员的建议算法。
