Ma Yi, Kong XianMing, Dai HuiLi, Wang LiMin, Zhu LiJun
Department of Biobank, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200127, China.
Int J Androl. 2012 Apr;35(2):170-5. doi: 10.1111/j.1365-2605.2011.01208.x. Epub 2011 Aug 10.
Clinical left-over biosamples are an important source for medical research. Our aim is to ascertain the attitudes of andrology patients towards biosample donation. A survey of 866 andrology patients with diverse andrology conditions was conducted in Shanghai, China from May 2010 to December 2010. The response rate was 75.8%. Of the study patients, 61.4% (95% confidence interval, CI: 0.58-0.65) voiced the opinion that they were willing to donate the residual biosample; 32.0% refused to donate; and 6.6% stated that they were undecided. Unwillingness to give sample was independently associated with having a low level of education (p = 0.047, OR = 0.63, 95% CI: 0.39-0.995) and being infertile patients (p = 0.03, OR = 0.61, 95% CI: 0.39-0.95), while willingness was significantly associated with being cancer patients (p = 0.04, OR = 1.90, 95% CI: 1.03-3.50), being aged 18-29 years (p < 0.01, OR = 5.88, 95% CI: 2.85-12.16) and being aged 30-44 years (p = 0.01, OR = 2.17, 95% CI: 1.20-3.90). Most andrology patients would want to authorize every future research by themselves (82.4%) and obtain their individual research results (75.7%). Less than half of the willing respondents would want to donate semen (44.1%) and testis (41.3%). The results suggested that andrology patients' willingness to donate samples was low, especially in case of infertile patients. More studies are required to elucidate further causes for the low willingness to donate sample among andrology patients.
临床剩余生物样本是医学研究的重要来源。我们的目的是确定男科患者对生物样本捐赠的态度。2010年5月至2010年12月在中国上海对866名患有各种男科疾病的患者进行了一项调查。回复率为75.8%。在研究患者中，61.4%（95%置信区间，CI：0.58 - 0.65）表示愿意捐赠剩余生物样本；32.0%拒绝捐赠；6.6%表示未决定。不愿意提供样本与低教育水平（p = 0.047，OR = 0.63，95% CI：0.39 - 0.995）和不育患者（p = 0.03，OR = 0.61，95% CI：0.39 - 0.95）独立相关，而愿意捐赠与癌症患者（p = 0.04，OR = 1.90，95% CI：1.03 - 3.50）、年龄在18 - 29岁（p < 0.01，OR = 5.88，95% CI：2.85 - 12.16）和年龄在30 - 44岁（p = 0.01，OR = 2.17，95% CI：1.20 - 3.90）显著相关。大多数男科患者希望自己授权未来的每项研究（82.4%）并获得个人研究结果（75.7%）。愿意捐赠的受访者中不到一半愿意捐赠精液（44.1%）和睾丸（41.3%）。结果表明，男科患者捐赠样本的意愿较低，尤其是不育患者。需要更多研究来阐明男科患者捐赠样本意愿低的进一步原因。
