Department of Pediatric General Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Cancer Med. 2022 Mar;11(6):1524-1534. doi: 10.1002/cam4.4544. Epub 2022 Feb 3.
This study examined and compared the attitudes and willingness of guardians of children with cancer and adult cancer patients toward donating biospecimens and clinical data for cancer research.
We conducted a cross-sectional study among guardians of children with cancer (Guardian group) from Shanghai Children's Medical Center and adult cancer patients (Adult group) from Shanghai Ninth People's Hospital between February 1, 2019, and January 31, 2020. Participants' demographic data, willingness, and motivations for biospecimen donation were collected and analyzed.
Of 670 participants, 90.8% (318/350) in the Guardian group and 88.1% (282/320) in the Adult group completed the questionnaire. Most participants were willing to donate residual tissue samples (92.8% in the Guardian group vs. 79.4% in the Adult group, p = 0.032) and clinical data (94.0% vs. 72.3%, p < 0.001) for medical research. Logistic regression analysis indicated that only child status (odds ratio [OR] = 0.140, p = 0.02), history of blood donation (OR = 4.467, p = 0.019) in the Guardian group, education (OR = 0.387, p = 0.037), and history of blood donation (OR = 2.556, p = 0.016) in the Adult group were significantly associated with participants' willingness to donate biospecimens. The primary motivation for donation was helping other patients with cancer (65.4% vs. 24.5%, p < 0.001). The major barriers to donation were the potential to cause physical discomfort (61.0% vs. 64.9%, p = 0.032).
Guardians of children with cancer were more willing to donate biospecimens than adult cancer patients in China. It is essential to promote awareness of biospecimens donation, especially in adult cancer patients.
本研究旨在调查和比较癌症患儿的监护人以及成年癌症患者对捐赠生物样本和临床数据用于癌症研究的态度和意愿。
本研究于 2019 年 2 月 1 日至 2020 年 1 月 31 日期间，在上海儿童医学中心的癌症患儿监护人（监护人组）和上海第九人民医院的成年癌症患者（成年组）中开展了一项横断面研究。收集并分析了参与者的人口统计学数据、捐赠意愿以及捐赠生物样本的动机。
在 670 名参与者中，318 名（90.8%）监护人组和 282 名（88.1%）成年组完成了问卷调查。大多数参与者愿意为医学研究捐赠剩余组织样本（监护人组 92.8%，成年组 79.4%，p=0.032）和临床数据（监护人组 94.0%，成年组 72.3%，p<0.001）。Logistic 回归分析表明，仅子女状况（比值比[OR] 0.140，p=0.02）、监护人组的献血史（OR 4.467，p=0.019）、教育程度（OR 0.387，p=0.037）以及成年组的献血史（OR 2.556，p=0.016）与参与者捐赠生物样本的意愿显著相关。捐赠的主要动机是帮助其他癌症患者（监护人组 65.4%，成年组 24.5%，p<0.001）。捐赠的主要障碍是潜在的身体不适（监护人组 61.0%，成年组 64.9%，p=0.032）。
中国癌症患儿的监护人比成年癌症患者更愿意捐赠生物样本。必须提高对生物样本捐赠的认识，尤其是在成年癌症患者中。
