Kuhn E, Stefanits K, Dérczy K
Pécsi Orvostudományi Egyetem Radiológiai Klinika.
Orv Hetil. 1990 Apr 8;131(14):739-42.
Six out of 204 patients with Hodgkin's disease developed second malignant tumours 25, 30, 61, 65, 68 and 130 months following their treatment. The length of follow-up ranged between 24-233 months with a mean value of 95.8 months. Half of the tumours appeared within the volume irradiated. Five patients received radio- and polychemotherapy, only but one radiotherapy alone. The location of tumours found was as follows: 1 melanoma of the skin, 1 adenocarcinoma of the nasopharynx, 1 cancer of the rectum, 1 renal cell cancer as well as two cancers of the lung. Four patients are living following treatment of their secondary tumour. Until now no case of acute leukaemia could be observed.
204例霍奇金病患者中有6例在治疗后25、30、61、65、68和130个月发生了第二原发性肿瘤。随访时间为24至233个月，平均为95.8个月。一半的肿瘤出现在照射野内。5例患者接受了放疗和多药化疗，仅1例单独接受了放疗。所发现肿瘤的部位如下：1例皮肤黑色素瘤、1例鼻咽癌、1例直肠癌、1例肾细胞癌以及2例肺癌。4例患者在继发肿瘤治疗后仍存活。到目前为止，未观察到急性白血病病例。
