Joint Replacement Center of Korea, Ewha Womans University School of Medicine, Seoul, South Korea.
J Arthroplasty. 2011 Oct;26(7):1095-9. doi: 10.1016/j.arth.2011.03.052. Epub 2011 Aug 9.
We performed a prospective, double-blinded, randomized, and controlled study to assess the clinical efficacy and safety of intra-articular multimodal drug injection after total knee arthroplasty. Two hundred eighty-six patients undergoing simultaneous bilateral total knee arthroplasty were randomized to receive the injection of multimodal drugs in one knee and normal saline solution as a placebo in the contralateral knee. All patients received patient-controlled analgesia for 48 hours after surgery, followed by standard analgesia. Visual analog scores for pain during activity and rest and for patient satisfaction were recorded. The range of motion and blood loss were also recorded. Intraoperative intra-articular injection of multimodal drugs into the knee did not improve patient pain and satisfaction, range of motion, or blood loss compared with the placebo control.
我们进行了一项前瞻性、双盲、随机、对照研究，评估全膝关节置换术后关节内多模式药物注射的临床疗效和安全性。286 例同期双侧全膝关节置换术患者随机分为膝关节注射多模式药物，对侧膝关节注射生理盐水作为安慰剂。所有患者术后均接受 48 小时自控镇痛，随后给予标准镇痛。记录活动和休息时疼痛的视觉模拟评分以及患者满意度。还记录了关节活动度和失血量。与安慰剂对照组相比，膝关节内注射多模式药物并未改善患者疼痛和满意度、关节活动度或失血量。
