Mental Health Center, West China Hospital of Sichuan University, Chengdu, China.
Psychiatry Res. 2011 Oct 31;194(1):47-53. doi: 10.1016/j.pscychresns.2011.01.010. Epub 2011 Aug 9.
The previous task-based or resting perfusion studies in social anxiety disorder (SAD) patients have highlighted specific differences in brain response. Little is known about the changes in the local synchronization of spontaneous functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signals that occur in SAD during the resting state. We investigated altered neural activity in the resting state using a regional homogeneity (ReHo) analysis on 20 SAD and 20 healthy controls (HC). Compared with HC, SAD patients exhibited decreased coherence (ReHo) in the bilateral angular gyrus and the left medial prefrontal cortex within the default mode network (DMN), suggesting functional impairment of the perception of socially relevant emotional state and self-related mental representations; and also in the right dorsolateral prefrontal cortex and right inferior parietal gyrus within the central-executive network (CEN), reflecting the deficit of cognitive control of social anxiety. Significantly increased coherence (ReHo) was found in the left middle occipital gyrus, which would be consistent with their hypervigilance and hyperprosexia to the social communication even in the resting state. Our results might supply a novel way to look into neuro-pathophysiological mechanisms in SAD patients.
先前针对社交焦虑障碍 (SAD) 患者的基于任务或静息状态的灌注研究强调了大脑反应的特定差异。关于 SAD 患者在静息状态下局部自发功能磁共振成像 (fMRI) 血氧水平依赖 (BOLD) 信号同步性变化知之甚少。我们使用 20 名 SAD 患者和 20 名健康对照者 (HC) 的局部一致性 (ReHo) 分析研究了静息状态下的改变的神经活动。与 HC 相比，SAD 患者在默认模式网络 (DMN) 中的双侧角回和左侧内侧前额叶皮层以及中央执行网络 (CEN) 中的右侧背外侧前额叶皮层和右侧顶下小叶中表现出连贯性降低 (ReHo)，这表明对与社会相关的情绪状态和自我相关的心理表现的感知功能受损; 还反映了社交焦虑的认知控制不足。在左侧中枕叶回中发现了显著增加的连贯性 (ReHo)，这与他们在静息状态下对社会交流的过度警觉和过度关注一致。我们的研究结果可能为研究 SAD 患者的神经病理生理机制提供了一种新的方法。
