School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Curr Opin Plant Biol. 2011 Dec;14(6):658-65. doi: 10.1016/j.pbi.2011.07.006. Epub 2011 Aug 8.
The endoplasmic reticulum (ER) in higher plants performs many important functions, yet our understanding of how its intricate network shape and dynamics relate to function is very limited. Recent work has begun to unpick key molecular players in the generation of the pleomorphic, highly dynamic ER network structure that pervades the entire cytoplasm. ER movement is acto-myosin dependent. ER shape is dependent on RHD3 (Root Hair Defective 3) and a family of proteins called reticulons. The major challenge that lies ahead is understanding how factors that control ER shape and movement are regulated and how this relates to the numerous functions of the ER.
高等植物的内质网(ER)具有许多重要的功能,但我们对于其复杂的网络形状和动态如何与其功能相关的理解非常有限。最近的研究开始揭示在形成遍及整个细胞质的多形性、高度动态 ER 网络结构中起关键作用的分子。ER 的运动依赖于肌动球蛋白。ER 的形状依赖于 RHD3(根毛缺陷 3)和一类称为网质蛋白的蛋白质。摆在面前的主要挑战是了解控制 ER 形状和运动的因素是如何被调控的,以及这与 ER 的众多功能有何关系。