Department of Medical Oncology, Beth Israel Medical Center, 325 W. 15th Street, New York, NY 10011, USA.
Clin Breast Cancer. 2011 Dec;11(6):417-9. doi: 10.1016/j.clbc.2011.06.006. Epub 2011 Aug 10.
Testosterone is important for the development of secondary sexual characteristics in female-to-male (FtM) transsexuals, but it may increase breast cancer risk. To date, only one breast cancer case has been reported in the literature in a FtM transsexual after 10 years of testosterone therapy. We describe 2 cases of breast cancers diagnosed in FtM transsexuals who have been treated with supraphysiological doses of testosterone. Our 2 cases demonstrate the unique issues that concern the management of FtM transsexuals with breast cancer and examine possible roles of testosterone in the development of breast cancer.
睾丸酮对于女变男（FtM）变性人第二性征的发育很重要，但它可能会增加乳腺癌的风险。迄今为止，文献中仅报道过一例 FtM 变性人在接受了 10 年睾丸酮治疗后发生乳腺癌。我们描述了 2 例接受超生理剂量睾丸酮治疗的 FtM 变性人乳腺癌病例。我们的这 2 个病例显示了与 FtM 变性人乳腺癌管理相关的独特问题，并探讨了睾丸酮在乳腺癌发生中的可能作用。
