Hockfield S, Tootell R B, Zaremba S
Section of Neuroanatomy, Yale University School of Medicine, New Haven, CT 06510.
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3027-31. doi: 10.1073/pnas.87.8.3027.
Monoclonal antibody Cat-301 recognizes a cell-surface proteoglycan on subsets of neurons in several areas of the cat and macaque monkey central nervous system. In striate and extrastriate visual cortex of the macaque, the distribution of Cat-301-positive neurons demonstrates features of cellular organization that correlate with previously described functional subdivisions. Here we show that Cat-301 recognizes an antigen in human cortex that is closely related, if not identical, to the antigen in laboratory animals. Further, we use Cat-301 to demonstrate an organization of molecularly defined neurons in primary and secondary visual cortex (cortical areas V1 and V2) of the human. The organization demonstrated with Cat-301 in human area V1 correlates with the organization of ocular dominance columns demonstrated by cytochrome oxidase histochemistry. The organization demonstrated with Cat-301 in human area V2 correlates with the thick stripes of the cytochrome oxidase pattern. The present observations provide evidence for a visual pathway in human cortex homologous to the magnocellular pathway in macaque, a pathway involved in processing the low-contrast, achromatic, and moving components of visual stimuli.
单克隆抗体Cat-301可识别猫和猕猴中枢神经系统多个区域中神经元亚群上的一种细胞表面蛋白聚糖。在猕猴的纹状和纹外视觉皮层中，Cat-301阳性神经元的分布呈现出与先前描述的功能细分相关的细胞组织特征。在此我们表明，Cat-301识别的人类皮层中的一种抗原，即便与实验动物中的抗原不完全相同，也密切相关。此外，我们利用Cat-301来展示人类初级和次级视觉皮层（皮层区域V1和V2）中分子定义的神经元的一种组织形式。用Cat-301在人类V1区域所展示的这种组织形式与细胞色素氧化酶组织化学所显示的眼优势柱的组织形式相关。用Cat-301在人类V2区域所展示的这种组织形式与细胞色素氧化酶模式的粗条纹相关。目前的观察结果为人类皮层中与猕猴的大细胞通路同源的视觉通路提供了证据，该通路参与处理视觉刺激的低对比度、无色和运动成分。
