Zhang Lei, Qiao Shi Zhang, Cheng Lina, Yan Zifeng, Lu Gao Qing Max
College of Chemistry and Chemical Engineering, China University of Petroleum, Dongying 257061, People's Republic of China. ARC Centre of Excellence for Functional Nanomaterials, School of Engineering and Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD 4072, Australia.
Nanotechnology. 2008 Oct 29;19(43):435608. doi: 10.1088/0957-4484/19/43/435608. Epub 2008 Sep 22.
We report a one-step synthesis of magnetic helical mesostructured silica (MHMS) by self-assembly of an achiral surfactant, magnetic nanocrystals with stearic acid ligands and silicate. This core-shell structured material consists of an Fe(3)O(4) superparamagnetic nanocrystal core and a highly ordered periodic helical mesoporous silica shell. We propose that the formation of the helical structure is induced by the interaction between the surfactant and dissociated stearic acid ligands. The MHMS obtained possesses superparamagnetism, uniform mesostructure, narrow pore size distribution, high surface area, and large pore volume. Furthermore, the drug release process is demonstrated using aspirin as a drug model and MHMS as a drug carrier in a sodium phosphate buffer solution.
我们报道了通过非手性表面活性剂、具有硬脂酸配体的磁性纳米晶体和硅酸盐的自组装一步合成磁性螺旋介孔二氧化硅（MHMS）。这种核壳结构材料由Fe(3)O(4)超顺磁性纳米晶体核和高度有序的周期性螺旋介孔二氧化硅壳组成。我们提出螺旋结构的形成是由表面活性剂与解离的硬脂酸配体之间的相互作用诱导的。所获得的MHMS具有超顺磁性、均匀的介孔结构、窄的孔径分布、高比表面积和大孔体积。此外，以阿司匹林为药物模型，以MHMS为药物载体，在磷酸钠缓冲溶液中演示了药物释放过程。
