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从铁磁流体中的单核纳米颗粒到多核磁性纳米复合材料：组装策略、结构及磁行为

From Single-Core Nanoparticles in Ferrofluids to Multi-Core Magnetic Nanocomposites: Assembly Strategies, Structure, and Magnetic Behavior.

作者信息

Krasia-Christoforou Theodora, Socoliuc Vlad, Knudsen Kenneth D, Tombácz Etelka, Turcu Rodica, Vékás Ladislau

机构信息

Department of Mechanical and Manufacturing Engineering, University of Cyprus, 75, Kallipoleos Avenue, P.O. Box 20537, 1678 Nicosia, Cyprus.

Laboratory of Magnetic Fluids, Center for Fundamental and Advanced Technical Research, Romanian Academy-Timisoara Branch, Mihai Viteazul Ave. 24, 300223 Timisoara, Romania.

出版信息

Nanomaterials (Basel). 2020 Oct 31;10(11):2178. doi: 10.3390/nano10112178.

DOI:10.3390/nano10112178
PMID:33142887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7692798/
Abstract

Iron oxide nanoparticles are the basic components of the most promising magnetoresponsive nanoparticle systems for medical (diagnosis and therapy) and bio-related applications. Multi-core iron oxide nanoparticles with a high magnetic moment and well-defined size, shape, and functional coating are designed to fulfill the specific requirements of various biomedical applications, such as contrast agents, heating mediators, drug targeting, or magnetic bioseparation. This review article summarizes recent results in manufacturing multi-core magnetic nanoparticle (MNP) systems emphasizing the synthesis procedures, starting from ferrofluids (with single-core MNPs) as primary materials in various assembly methods to obtain multi-core magnetic particles. The synthesis and functionalization will be followed by the results of advanced physicochemical, structural, and magnetic characterization of multi-core particles, as well as single- and multi-core particle size distribution, morphology, internal structure, agglomerate formation processes, and constant and variable field magnetic properties. The review provides a comprehensive insight into the controlled synthesis and advanced structural and magnetic characterization of multi-core magnetic composites envisaged for nanomedicine and biotechnology.

摘要

氧化铁纳米颗粒是最具前景的用于医学（诊断与治疗）及生物相关应用的磁响应纳米颗粒系统的基本组成部分。具有高磁矩且尺寸、形状和功能涂层明确的多核氧化铁纳米颗粒旨在满足各种生物医学应用的特定要求，如造影剂、热介质、药物靶向或磁性生物分离。这篇综述文章总结了制造多核磁性纳米颗粒（MNP）系统的最新成果，重点强调了合成过程，从作为各种组装方法主要材料的铁磁流体（含单核MNP）开始，以获得多核磁性颗粒。在介绍合成与功能化之后，将阐述多核颗粒先进的物理化学、结构和磁性表征结果，以及单核和多核颗粒的尺寸分布、形态、内部结构、团聚体形成过程，还有恒定和可变场磁性特性。该综述全面深入地探讨了设想用于纳米医学和生物技术的多核磁性复合材料的可控合成以及先进的结构和磁性表征。

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