Allergy Department, Vall d'Hebron Hospital, Barcelona, Spain.
Respiration. 2012;83(3):239-44. doi: 10.1159/000329440. Epub 2011 Aug 11.
Exhaled nitric oxide (ENO) is used as a marker of airway inflammation. Factors such as spirometric maneuvers (SPM), β(2)-agonists, or tobacco smoking have been postulated to affect ENO measurements. Guidelines on measurement techniques have been published based on expert opinions. Nevertheless, there is no strong clinical evidence of many aspects because they have not been supported by research data.
The aim of this study was to evaluate the influence of performing a spirometry or receiving inhaled salbutamol on ENO readings.
One hundred forty-five adults and 62 children with allergic asthma were included with a mean age of 36 ± 13 years for adults and 13 ± 2 years for children. A control group comprised 30 healthy adults and 30 children with a mean age of 37 ± 14 years and 13 ± 2 years, respectively. ENO measurements were performed with a NIOX-MINO® electrochemical device. In 179 patients ENO was measured before and after performing SPM and in 88 patients before and 15 min after SPM plus 2 puffs of salbutamol (100 μg/puff).
There were no significant differences in mean ENO levels before and after SPM or before and after SPM plus 2 puffs of inhaled salbutamol in adults or children (asthmatic or healthy).
Levels of ENO are not significantly affected by SPM or salbutamol inhalation.
呼出气一氧化氮（ENO）被用作气道炎症的标志物。有人推测，肺量计操作（SPM）、β（2）-激动剂或吸烟等因素会影响 ENO 的测量。已经根据专家意见发布了关于测量技术的指南。然而，由于缺乏研究数据的支持，许多方面都没有强有力的临床证据。
本研究旨在评估进行肺量计检查或吸入沙丁胺醇对 ENO 读数的影响。
共纳入 145 名成年和 62 名儿童变应性哮喘患者，成年患者的平均年龄为 36 ± 13 岁，儿童患者的平均年龄为 13 ± 2 岁。对照组包括 30 名健康成年人和 30 名儿童，平均年龄分别为 37 ± 14 岁和 13 ± 2 岁。使用 NIOX-MINO®电化学设备进行 ENO 测量。在 179 名患者中，在进行 SPM 前后测量了 ENO，在 88 名患者中，在进行 SPM 前后 15 分钟测量了 ENO，且在 SPM 后吸入 2 喷沙丁胺醇（每喷 100μg）。
在成年患者和儿童患者（哮喘或健康）中，SPM 前后或 SPM 加 2 喷吸入沙丁胺醇前后的 ENO 平均水平均无显著差异。
ENO 水平不受 SPM 或沙丁胺醇吸入的显著影响。
