妊娠期间胰岛素样生长因子-I 和 C 反应蛋白与非上皮性卵巢癌的母亲患病风险：一项巢式病例对照研究。

Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case-control study.

机构信息

National Institute for Health and Welfare, Finland.

出版信息

Cancer Causes Control. 2011 Nov;22(11):1607-11. doi: 10.1007/s10552-011-9828-2. Epub 2011 Aug 11.

DOI:10.1007/s10552-011-9828-2

PMID:21833488

Abstract

BACKGROUND

Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC).

METHODS

A case-control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case.

RESULTS

Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58-1.62) or GCT (OR 1.13, 95% CI 0.51-2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85-1.43) or GCT (OR 0.93, 95% CI 0.68-1.28).

CONCLUSIONS

Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.

摘要

背景

胰岛素样生长因子-I（IGF-I）和 C 反应蛋白（CRP）可能与上皮性卵巢癌（EOC）的风险呈正相关，但以前的研究并未探讨它们与非上皮性卵巢癌（NEOC）的关系。

方法

本病例对照研究嵌套在芬兰母婴队列中。病例组为招募后诊断为性索-间质肿瘤（SCST）的 58 名女性和生殖细胞肿瘤（GCT）的 30 名女性。对照组（SCST 为 144 名，GCT 为 74 名）按年龄、产次和病例采血日期与病例相匹配。

结果

IGF-I 浓度加倍与 SCST（OR 0.97，95%CI 0.58-1.62）或 GCT（OR 1.13，95%CI 0.51-2.51）的母亲患病风险无关。同样，CRP 浓度加倍与 SCST（OR 1.10，95%CI 0.85-1.43）或 GCT（OR 0.93，95%CI 0.68-1.28）的母亲患病风险无关。