胰岛素样生长因子I与上皮性浸润性卵巢癌风险的肿瘤特征分析：欧洲癌症与营养前瞻性调查（EPIC）队列研究结果
Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort.
作者信息
Ose J, Fortner R T, Schock H, Peeters P H, Onland-Moret N C, Bueno-de-Mesquita H B, Weiderpass E, Gram I T, Overvad K, Tjonneland A, Dossus L, Fournier A, Baglietto L, Trichopoulou A, Benetou V, Trichopoulos D, Boeing H, Masala G, Krogh V, Matiello A, Tumino R, Popovic M, Obón-Santacana M, Larrañaga N, Ardanaz E, Sánchez M-J, Menéndez V, Chirlaque M-D, Travis R C, Khaw K-T, Brändstedt J, Idahl A, Lundin E, Rinaldi S, Kuhn E, Romieu I, Gunter M J, Merritt M A, Riboli E, Kaaks R
机构信息
Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany.
Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
出版信息
Br J Cancer. 2015 Jan 6;112(1):162-6. doi: 10.1038/bjc.2014.566. Epub 2014 Nov 4.
BACKGROUND
Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.
METHODS
We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations.
RESULTS
We observed no association between IGF-I and EOC overall or by tumour characteristics.
CONCLUSIONS
In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
背景
关于胰岛素样生长因子I（IGF-I）与上皮性卵巢癌（EOC）风险的前瞻性研究尚无定论。数据表明，风险关联因肿瘤特征而异。
方法
我们在欧洲癌症与营养前瞻性调查（EPIC）中开展了一项巢式病例对照研究，以按肿瘤特征评估IGF-I浓度与EOC风险（n = 565例病例）。采用多变量条件逻辑回归模型来估计关联。
结果
我们未观察到IGF-I与总体EOC或按肿瘤特征之间存在关联。
结论
在迄今为止最大规模的前瞻性研究中，IGF-I与EOC风险之间不存在关联。诊断前血清IGF-I浓度可能不会影响EOC风险。
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