Scheuer P J
Department of Chemistry, University of Hawaii, Monoa, Honolulu 96822.
Science. 1990 Apr 13;248(4952):173-7. doi: 10.1126/science.2183350.
Analysis of secondary metabolites derived from marine organisms has revealed a broad spectrum of novel molecular architecture. The function of these compounds in their natural habitat is linked to various aspects of species survival, and the compounds have also served as characteristic chemical markers through successive trophic levels. Fundamental questions concerning the locus of synthesis in complex and intricate assemblies of plants and animals and the pathways of biosynthesis are beginning to be answered. It is now apparent that the marine environment gives rise to some distinctive chemistry, which is generated along characteristic pathways. Some of the newly described compounds have already become valuable tools in biomedicine.
对源自海洋生物的次生代谢产物的分析揭示了广泛的新型分子结构。这些化合物在其天然栖息地的功能与物种生存的各个方面相关联,并且这些化合物还作为特征性化学标志物贯穿连续的营养级。关于动植物复杂且精细集合体中的合成位点以及生物合成途径的基本问题开始得到解答。现在很明显,海洋环境产生了一些独特的化学物质,它们是沿着特定途径生成的。一些新描述的化合物已成为生物医学中有价值的工具。