Kitagawa I, Kobayashi M
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Gan To Kagaku Ryoho. 1989 Jan;16(1):1-8.
Marine organisms comprise over half a million species. Due to their unusual living environment as compared with terrestrial organisms, marine organisms produce a variety of metabolic substances which often have various unprecedented chemical structures. In recent years, an increasing number of marine natural products have been reported to exhibit various biological activities such as antimicrobial, physiological, and pharmacological ones. Some metabolites have also been noted by their significant toxicities. The effort to find out anti-tumor substances from marine organisms has been also undertaken in recent years, and several novel compounds (e.g. peptide, polyether, alkaloid, prostanoid etc.), with anti-tumor activities, have been isolated from marine sponges, octocorals, marine algae, tunicates, nudibranchs, bryozoans, and so on. In this article, those chemically clarified anti-tumor compounds isolated from marine organisms were reviewed.
海洋生物包含超过五十万个物种。与陆地生物相比，由于其独特的生存环境，海洋生物产生了各种各样的代谢物质，这些物质往往具有各种前所未有的化学结构。近年来，越来越多的海洋天然产物被报道具有抗菌、生理和药理等多种生物活性。一些代谢产物也因其显著的毒性而受到关注。近年来人们也致力于从海洋生物中寻找抗肿瘤物质，并且已经从海洋海绵、八放珊瑚、海藻、被囊动物、裸鳃亚目动物、苔藓虫等生物中分离出了几种具有抗肿瘤活性的新型化合物（如肽、聚醚、生物碱、前列腺素等）。本文对从海洋生物中分离出的那些化学性质明确的抗肿瘤化合物进行了综述。
