Department of Urology, Hospital Clínic de Barcelona, Barcelona, Spain.
World J Urol. 2012 Jun;30(3):361-5. doi: 10.1007/s00345-011-0741-9. Epub 2011 Aug 11.
Relationship between prostate cancer (PCa) and testosterone (T) is controversial. Conflicting evidence has been published about T levels and development of PCa.
(1) To determine the relationship between hormone levels and the diagnosis of PCa. (2) To specifically focus on the relationship between PCa and T in men classified as biochemically hypogonadal.
Prospective analysis of 1,000 transrectal ultrasound guided prostate biopsies (5 + 5 cores biopsies) between September 2007 and January 2010 in one center. Indication for prostate biopsy was suspicion of PCa on the basis of elevated prostate-specific antigen (PSA) and/or digital rectal examination (DRE). Serum testosterone and sex hormones binding globulin (SHBG) were determined in these patients. Of 557 men, the data were sufficient for further analysis. Age, body mass index (BMI), smoking/drinking habits, PSA, free PSA, PSA density, prostate volume, number of previous biopsies, DRE, and hormone levels were prospectively recorded.
No relationship was found between T and PCa (449 ± 167 ng/dL in PCa versus 437 ± 169 ng/dL in non-PCa). SHBG was significantly higher in patients with PCa (51 ± 27 ng/dL in PCa vs. 44 ± 18 ng/dL in non-PCa). In hypogonadal men, T levels correlated with the PCa (235 ± 95 ng/dL in men with PCa versus 270 ± 58 ng/dL in men without PCa, P = 0.004).
T levels were comparable in men with and without PCa, but SHBG levels were significantly higher in men with PCa. In men with low T, the men with PCa had a lower serum T levels and a lower prostate volume than the men without PCa.
前列腺癌（PCa）与睾丸激素（T）之间的关系存在争议。关于 T 水平与 PCa 发展之间的关系，已经发表了相互矛盾的证据。
（1）确定激素水平与 PCa 诊断之间的关系。（2）专门关注被归类为生物性性腺功能减退的男性中 PCa 与 T 之间的关系。
对 2007 年 9 月至 2010 年 1 月在一个中心进行的 1000 例经直肠超声引导前列腺活检（5+5 芯活检）进行前瞻性分析。前列腺活检的指征是基于前列腺特异性抗原（PSA）升高和/或直肠指检（DRE）怀疑 PCa。这些患者测定血清睾丸激素和性激素结合球蛋白（SHBG）。在 557 名男性中，有足够的数据进行进一步分析。前瞻性记录年龄、体重指数（BMI）、吸烟/饮酒习惯、PSA、游离 PSA、PSA 密度、前列腺体积、既往活检次数、DRE 和激素水平。
T 与 PCa 之间未发现相关性（PCa 中为 449±167ng/dL，非 PCa 中为 437±169ng/dL）。PCa 患者的 SHBG 明显较高（PCa 中为 51±27ng/dL，非 PCa 中为 44±18ng/dL）。在性腺功能减退的男性中，T 水平与 PCa 相关（PCa 中为 235±95ng/dL，非 PCa 中为 270±58ng/dL，P=0.004）。
T 水平在有和没有 PCa 的男性中相似，但 SHBG 水平在有 PCa 的男性中明显较高。在 T 水平较低的男性中，患有 PCa 的男性的血清 T 水平和前列腺体积低于不患有 PCa 的男性。
