Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Millet Cad., Capa-Istanbul, 34390, Turkey.
Pituitary. 2012 Sep;15(3):386-92. doi: 10.1007/s11102-011-0332-1.
The aim was to evaluate the concentrations of lipid subfractions in relation to adipokines and metabolic parameters in adult growth hormone (GH)-deficient hypopituitary patients on conventional replacement therapy. The study included 21 GH deficient-hypopituitary patients (age: 36.0 ± 15.1 years, male/female: 7/14) on conventional replacement therapy other than GH and 20 comparable controls (age: 37.3 ± 14.0 years, male/female: 6/14). Lipid subfractions (Lipoprint system), serum adipokine (leptin, adiponectin, resistin) concentrations, body composition, a surrogate marker for insulin resistance (HOMA) and conventional lipid profile were evaluated. No statistically significant difference was found with respect to HOMA, adipokine concentrations and anthropometric parameters between patients and controls except for significantly increased waist-to-hip ratio in hypopituitary group. Total and LDL cholesterol concentrations were significantly higher in the patients. LDL particle size (268.88 ± 3.16 vs. 271.31 ± 3.11 Å, P = 0.151) and small-dense LDL subfraction did not differ significantly. According to logistic regression analysis, triglyceride concentrations ≥1.69 mmol/L was the sole parameter significantly and independently predicted small (<268 Å) LDL particle size (P = 0.019) in the whole group. Increased triglyceride concentrations affect LDL particle size in GH-deficient hypopituitary patients. Small dense LDL seems not directly contribute to atherogenic potential in hypopituitarism.
目的在于评估脂类亚组分浓度与成人生长激素（GH）缺乏性垂体功能减退症患者的脂肪因子和代谢参数之间的关系。该研究纳入了 21 名正在接受除 GH 以外的常规替代疗法的 GH 缺乏性垂体功能减退症患者（年龄：36.0±15.1 岁，男/女：7/14）和 20 名可比对照组（年龄：37.3±14.0 岁，男/女：6/14）。评估了脂类亚组分（Lipoprint 系统）、血清脂肪因子（瘦素、脂联素、抵抗素）浓度、身体成分、胰岛素抵抗的替代标志物（HOMA）和常规血脂谱。除了垂体功能减退组的腰围/臀围比显著增加外，患者和对照组之间在 HOMA、脂肪因子浓度和人体测量参数方面没有统计学上的显著差异。患者的总胆固醇和 LDL 胆固醇浓度显著升高。LDL 颗粒大小（268.88±3.16 对 271.31±3.11 Å，P=0.151）和小而密 LDL 亚组分没有显著差异。根据逻辑回归分析，甘油三酯浓度≥1.69 mmol/L 是唯一显著且独立地预测整个组中 LDL 颗粒大小小（<268 Å）的参数（P=0.019）。升高的甘油三酯浓度会影响 GH 缺乏性垂体功能减退症患者的 LDL 颗粒大小。小而密的 LDL 似乎不会直接导致垂体功能减退症的动脉粥样硬化潜力增加。
